Pertuzumab protects the achilles' heel of trastuzumab--emtansine.

نویسندگان

  • William R Gwin
  • Neil L Spector
چکیده

Trastuzumab emtansine (T-DM1) represents a significant advancement in the treatment of HER2(+) breast cancers. Its clinical efficacy however will be limited by the development of therapeutic resistance. In this report, the HER3 ligand neuregulin is shown to mediate T-DM1 resistance, which was overcome by administration of pertuzumab, a steric inhibitor of HER2 dimerization.

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عنوان ژورنال:
  • Clinical cancer research : an official journal of the American Association for Cancer Research

دوره 20 2  شماره 

صفحات  -

تاریخ انتشار 2014